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Abstract One key challenge in the field of topological superconductivity (Tsc) has been the rareness of material realization. This is true not only for the first-order Tsc featuring Majorana surface modes, but also for the higher-order Tsc, which host Majorana hinge and corner modes. Here, we propose a four-step strategy that mathematically derives comprehensive guiding principles for the search and design for materials of general higher-order Tsc phases. Specifically, such recipes consist of conditions on the normal state and pairing symmetry that can lead to a given higher-order Tsc state. We demonstrate this strategy by obtaining recipes for achieving three-dimensional higher-order Tsc phases protected by the inversion symmetry. Following our recipe, we predict that the observed superconductivity in centrosymmetric MoTe₂is a hyrbid-order Tsc candidate, which features both surface and corner modes. Our proposed strategy enables systematic materials search and design for higher-order Tsc, which can mobilize the experimental efforts and accelerate the material discovery for higher-order Tsc phases. 

(3+1)D topological phases of matter can host a broad class of non-trivial topological defects of codimension-1, 2, and 3, of which the well-known point charges and flux loops are special cases. The complete algebraic structure of these defects defines a higher category, and can be viewed as an emergent higher symmetry. This plays a crucial role both in the classification of phases of matter and the possible fault-tolerant logical operations in topological quantum error-correcting codes. In this paper, we study several examples of such higher codimension defects from distinct perspectives. We mainly study a class of invertible codimension-2 topological defects, which we refer to as twist strings. We provide a number of general constructions for twist strings, in terms of gauging lower dimensional invertible phases, layer constructions, and condensation defects. We study some special examples in the context of \mathbb{Z}_2 ℤ 2 gauge theory with fermionic charges, in \mathbb{Z}_2 \times \mathbb{Z}_2 ℤ 2 × ℤ 2 gauge theory with bosonic charges, and also in non-Abelian discrete gauge theories based on dihedral ( D_n D n ) and alternating ( A_6 A 6 ) groups. The intersection between twist strings and Abelian flux loops sources Abelian point charges, which defines an H^4 H 4 cohomology class that characterizes part of an underlying 3-group symmetry of the topological order. The equations involving background gauge fields for the 3-group symmetry have been explicitly written down for various cases. We also study examples of twist strings interacting with non-Abelian flux loops (defining part of a non-invertible higher symmetry), examples of non-invertible codimension-2 defects, and examples of the interplay of codimension-2 defects with codimension-1 defects. We also find an example of geometric, not fully topological, twist strings in (3+1)D A_6 A 6 gauge theory.